![]() If the review of the maternal history and infectious disease testing are both within the bounds established by the bank, another sample is sent for HLA testing. If both are high enough, the unit is processed, and samples are taken for infectious disease testing. In most cases, the collected blood is then transported to the bank in order to obtain volume and cell count. This is either by providing the mother with a kit or, if the delivery hospital is affiliated with a bank, by noting it in the mother’s chart. Upon adequate completion of the informed consent (more on the informed consent process can be found in Chapter 5), the mother’s obstetrician is informed of her wish to be a donor, and arrangements are made to collect the cord blood. In most cases, a mother will register with a bank prior to giving birth. Figure 4-1 depicts the various aspects of the collection, storage, search and transplantation processes. This chapter discusses the results of a survey that the committee conducted to assess current cord blood banking practices describes procedures for the collecting and processing of cord blood discusses the procedures used to access units and delineates the current status of laws, regulations,Ī cord blood bank is a center whose central mission is to maintain a supply of cord blood for therapeutic use in transplantation. Thus, donor recruitment efforts should include greater attempts at outreach to populations whose HLA types are underrepresented in cord blood collections and the development of innovative approaches to donor recruitment. ![]() ![]() Finally, existing cord blood collections lack sufficient ethnic and racial diversity to ensure adequate probability of finding HLA-matched units for some ethnic and racial groups, which is a particularly important barrier to the fundamental goal of unimpeded access to needed treatment. Yet the rules are not standardized and a more consistently applied set of regulations would benefit both the cord blood banks and end users. Furthermore, difficulties with human leukocyte antigen (HLA) typing of HPCs to the level required for cells from adult and cord blood donors make it difficult to compare and contrast the results of a search for HPCs from these two types of HPC donor sources.įederal and state laws and regulations govern the operation of cord blood banks, and many are accredited through a variety of mechanisms. The absence of a standard, generally accepted search algorithm and differences in cord blood bank quality make it difficult for transplant physicians to know when it is most appropriate to use cord blood instead of an alternative sources of hematopoietic progenitor cells (HPCs). The centers that collect, process, and store umbilical cord blood differ in their organization and governance as well as in the cord blood processing methods that they use.
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